Plasma apolipoprotein E protein attenuates pulmonary fibrosis through LRP1 and PLAU dual receptor-mediated TGF-β/Smad inhibition
Plasma apoE is a causal guardian against pulmonary fibrogenesis, inhibiting TGF-β/Smad signaling through dual receptor (LRP1/PLAU) engagement. Cross-species validation and mechanistic elucidation position RGX-104, a small-molecule LXR agonist, as a potential therapeutic candidate for clinical translation in IPF.
Authors
- Huaqi Guo (ORCID: https://orcid.org/0009-0000-5151-7809)
- Weining Xiong (ORCID: https://orcid.org/0000-0003-1241-0480)
- Haiyang Zhang (ORCID: https://orcid.org/0000-0002-2410-7078)
- Lifeng Yan (ORCID: https://orcid.org/0000-0002-6063-270X)
- WenRu Shang
- Tianyu Zhou (ORCID: https://orcid.org/0000-0003-0515-7050)
- Manyi Pan (ORCID: https://orcid.org/0009-0000-4426-0531)
- Kai Zhang
- Gang Wei
- Yu Xie
- Juan Liu
- Yi Yan Wang
- Yuxin Zou
- Wangrui Liu
- Jiachang Chi
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Peking University (CN)
- Renji Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Hospital Development Center (CN)
- Shanghai Sixth People's Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.045
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00