Yin‐Yang 1/Neural Precursor Cell‐Expressed Developmentally Downregulated 4‐Like Axis Suppresses Mer Tyrosine Kinase‐Mediated Macrophage Efferocytosis to Exacerbate Atherosclerosis Via Triggering Pyroptosis
Our findings demonstrated that YY1 positively regulated NEDD4L to modulate MerTK-mediated efferocytosis and activate NLRP3-mediated inflammation and pyroptosis, thus exacerbating atherosclerosis.
Authors
- Wen Shen (ORCID: https://orcid.org/0000-0002-0862-2846)
- Tao Wu (ORCID: https://orcid.org/0000-0002-5750-909X)
- Ben Ke
- Zaihua Cheng
- Qiang Liu
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1161/jaha.124.039855
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00