The Uric Acid/HDL-Cholesterol Ratio as a Potential Marker of Obstruction in Hypertrophic Cardiomyopathy

Aim: The uric acid to high-density lipoprotein cholesterol ratio (UHR) has recently emerged as a composite metabolic–inflammatory marker linked to cardiovascular risk. However, its relevance in hypertrophic cardiomyopathy (HCM), particularly in distinguishing obstructive (HOCM) from non-obstructive (HNCM) forms, remains unknown. We aimed to investigate whether UHR differs between HOCM, HNCM, and healthy controls, and to determine its association with echocardiographic and inflammatory markers, as well as its diagnostic performance for identifying obstructive HCM. Methods: This retrospective study included 200 participants (60 HOCM, 80 HNCM, 60 controls). Clinical, biochemical, and echocardiographic data were analyzed. UHR was calculated as serum uric acid (mg/dL) divided by HDL-C (mg/dL). Correlation and receiver operating characteristic (ROC) analyses were performed. Results: UHR was significantly higher in HOCM than in HNCM and controls (p