Immune landscape and biomarker identification in Q fever: a comprehensive diagnostic analysis
This study delineates the landscape of gene expression and immune status alterations during QF progression. The identified hub genes (IL6, IL4, IL1B, AKT1, and CD28) hold promise as potential diagnostic biomarkers for AQF. Collectively, these findings provide critical insights into the immune-regulatory mechanisms of QF and offer valuable theoretical support for the development of clinical diagnostic tools and therapeutic strategies.
Authors
- Zhiyuan Gong (ORCID: https://orcid.org/0000-0002-9660-5260)
- Shixin Liu
Institutions
- Weifang People's Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1371/journal.pone.0339963
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00