Hydrogen Attenuates Oxidative Damage via NRF2-Mediated Mitophagy after Subarachnoid Hemorrhage
The NRF2-PINK1/Parkin axis is a novel and key mechanism underlying the neuroprotective effect of H<sub>2</sub> in SAH. This finding advances our understanding beyond general antioxidant theories by demonstrating a specific, multistep molecular cascade. H<sub>2</sub> administration is a potential mitochondrion-targeted intervention with strong implications for clinical translation in SAH patients. <i>Antioxid. Redox Signal.</i> 44, 443-463.
Authors
- Xiaolong Zhu (ORCID: https://orcid.org/0000-0003-1511-1566)
- J W Zhang
- Qing-Rong Zhang
- Pengfei Ding (ORCID: https://orcid.org/0000-0003-1824-724X)
- Zong Zhuang
- Qi Zhu
- Yan Zhou
- Zheng Peng
- Mingzhe Ning
Institutions
- Nanjing Drum Tower Hospital (CN)
- Nanjing Hydraulic Research Institute (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Antioxidants and Redox Signaling
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1177/15230864251410952
- Citations
- 1
- Primary Topic
- Hydrogen's biological and therapeutic effects
- Type
- article
- Field-Weighted Citation Impact
- 2.01