Sustained hippocampal neuroinflammation and subsequent glutamatergic dysfunction in juvenile idiopathic arthritis: evidence from proton magnetic resonance spectroscopy (1H-MRS)
Sustained hippocampal neuroinflammation (indicated by elevated mI/tCr) and the subsequent glutamatergic synaptic dysfunction (indicated by reduced Glu/tCr and Glx/tCr) were identified in JIA patients. Peripheral inflammation may drive microglial activation during active disease, highlighting the hippocampus as a vulnerable CNS target in chronic inflammatory states.
Authors
- Haiwei Han (ORCID: https://orcid.org/0009-0001-1048-9001)
- Jihong Xiao (ORCID: https://orcid.org/0009-0008-1707-9495)
- C. Han
- Shumu Yang
- Hua Wu
- Yifei Weng
- Cuili Yi
Institutions
- First Affiliated Hospital of Xiamen University (CN)
- The 180th Hospital of PLA (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1186/s13075-025-03695-5
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Natural Science Foundation of Fujian Province