Impact of Androgen Deprivation Therapy on Choroidal Microcirculation Assessed Using Laser Speckle Flowgraphy
Choroidal BOM increased significantly during the initial 6 months of ADT, indicating higher microvascular resistance despite stable choroidal blood flow and unchanged large artery stiffness. This supports a "microcirculation-first" model. LSFG-derived BOM may serve as a biomarker for early detection and monitoring of microcirculatory dysfunction under systemic testosterone suppression.
Authors
- Takatoshi Somoto
- Takanobu Utsumi (ORCID: https://orcid.org/0000-0003-4858-0641)
- Ryuya Hashimoto (ORCID: https://orcid.org/0000-0002-9806-0268)
- H. Suzuki
- Takahide Noro
- Ryo Oka (ORCID: https://orcid.org/0000-0003-1715-2222)
- Naoto Kamiya (ORCID: https://orcid.org/0000-0002-4183-2490)
- Moe Nunose
- Fumihiko Yagi
- Kazufumi Tanaka
- Naoki Fujioka
- Ryota Takenaka
- Sara Imai
Institutions
- Toho University (JP)
- Toho University Medical Center Sakura Hospital (JP)
Publication Details
- Journal
- Microcirculation
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1111/micc.70048
- Primary Topic
- Thermoregulation and physiological responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00