Synthesis of Uracil Containing Oxazolidinone Derivatives by Using Uracil-BX and NaHCO <sub>3</sub> as a Solid Surrogate of CO <sub>2</sub>
We report a straightforward Pd(II)-catalyzed three-component strategy for the synthesis of uracil-oxazolidinone hybrids, wherein NaHCO<sub>3</sub> acts as a solid CO<sub>2</sub> surrogate and the newly developed hypervalent iodine reagent Uracil-BX enables efficient construction of structurally diverse, medicinally relevant scaffolds under mild conditions. This method opens the door to access to uracil-oxazolidinone hybrids bearing a tetra-substituted alkene in good yield and very high <i>E-</i>stereoselectivity.
Authors
- Uttam Kumar Das (ORCID: https://orcid.org/0000-0002-0410-6190)
- Md. Abbasuddin Sk
- Manik Chandra Das (ORCID: https://orcid.org/0000-0001-9259-0068)
- Sukanya Das (ORCID: https://orcid.org/0009-0006-7829-7387)
- Raj K. Nandi
- Mainak Pramanik
- Sankar Singri
- Nityananda Dutta
Institutions
- Jadavpur University (IN)
- Mahatma Gandhi University (RW)
- Mahatma Gandhi Central University
- Indian Institute of Technology Kanpur (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1021/acs.orglett.5c04402
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00