Tumor-associated Neutrophils Promote Lung Cancer Growth and Metastasis <i>via</i> the Neutrophil Elastase
NE secreted by TANs in lung cancer tissues facilitates further TAN recruitment, leading to a TAN-rich TME that promotes tumor progression. Additionally, NE promotes distant metastasis by enhancing lung cancer cell motility and vascular invasion. These findings suggest that NE is a promising therapeutic target for lung cancer treatment.
Authors
- Yo Kawaguchi (ORCID: https://orcid.org/0000-0002-7828-4635)
- Yoko Kataoka (ORCID: https://orcid.org/0000-0001-6268-6587)
- Jun Hanaoka (ORCID: https://orcid.org/0000-0002-5272-556X)
- Makoto Yoden
- Takuya Shiratori (ORCID: https://orcid.org/0009-0002-5056-7112)
- HIROKI SAITO
- TOMOAKI SUZUKI
- KEIGO OKAMOTO
- DAIGO ISHIHARA
- KEIKO UEDA
Institutions
- Shiga University of Medical Science (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-12-30
- DOI
- https://doi.org/10.21873/anticanres.17932
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00