Neutrophil-macrophage crosstalk via NETs–IL-17/VEGF/S100A9 axis promotes hepatocellular carcinoma progression
A positive feedback loop between neutrophils and macrophages via the NETs-IL-17/VEGF/S100A9 axis accelerates HCC progression and metastasis. More importantly, NETs-IL-17 exhibited potential as an alternative biomarker for predicting extrahepatic metastasis in HCC.
Authors
- Jingying Zhou (ORCID: https://orcid.org/0000-0002-9740-6159)
- Shue Li
- Xuehua Kong
- Yaqian Duan
- Yuqing Zhao
- Liang Duan
- Rong Wu
- Rui Wu
- Shiyu Cao
- Xuanyi Wang
- Shan Yu
Institutions
- Chinese University of Hong Kong (HK)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1186/s13046-025-03618-x
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59