Unveiling the Impact of <i>Porphyromonas gingivalis</i> ‐Associated Periodontitis on Stroke Outcome in Mice
Our findings demonstrate that <i>P gingivalis</i>-associated periodontitis worsens ischemic stroke outcome both indirectly by enhancing systemic and brain inflammation and directly via BBB disruption. These results highlight periodontitis as a modifiable risk factor and potential therapeutic target for improving stroke prognosis.
Authors
- Sandrine Delbosc (ORCID: https://orcid.org/0000-0001-8076-6927)
- Marjolaine Gosset (ORCID: https://orcid.org/0000-0002-4875-7892)
- Antonino Nicoletti (ORCID: https://orcid.org/0000-0002-2623-0897)
- Jérôme Bouchet (ORCID: https://orcid.org/0000-0002-6611-4380)
- Banndith Cheat
- Jean‐Philippe Désilles (ORCID: https://orcid.org/0000-0001-8395-6312)
- Marc Clément (ORCID: https://orcid.org/0000-0002-6479-8360)
- Gabrielle Mangin (ORCID: https://orcid.org/0000-0002-1020-7473)
- Giuseppina Caligiuri (ORCID: https://orcid.org/0000-0003-4973-2205)
- Guillaume Even
- Anh‐Thu Gaston
- Dévy Diallo
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Inflammation Research Foundation (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1161/jaha.125.045997
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00