A hybrid curve-fitting method for radiation dosimetry evaluation and simultaneous multi-organ biodistribution assessment in total-body dynamic PET/CT: application to a novel PD-L1-targeted tracer
The radiation dosimetry results obtained from both the RM and the HM consistently support the safety and feasibility of total-body PET/CT imaging using [<sup>68</sup>Ga]Ga-NOTA-SNA002. Meanwhile, the HM provides theoretically more accurate results compared to the RM, and is therefore recommended for radiation dosimetry evaluation of other novel tracers.
Authors
- G. M. Liu (ORCID: https://orcid.org/0009-0001-4933-0276)
- Yunze Xie (ORCID: https://orcid.org/0009-0004-8517-6597)
- Wenxin Tang
- Lichao Zhang
- Hongcheng Shi
Institutions
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Zhongshan Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1186/s40658-025-00828-2
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00