Mitochondrial DNA‐Mediated Immune Activation After Resuscitation From Cardiac Arrest
Brief whole-body ischemia and reperfusion in the context of resuscitation from sudden cardiac arrest elicits mtDNA release, primarily within EVs, that triggers leukocyte activation. Targeting mtDNA release or its downstream sensors may offer a new therapeutic strategy to improve outcomes after sudden cardiac arrest.
Authors
- Brian R. Weil (ORCID: https://orcid.org/0000-0002-8832-6771)
- Tyler Rolland (ORCID: https://orcid.org/0000-0003-2700-8160)
- Swati D. Sonkawade
- Luke Graser
- Daniel Cucinotta
- Sumbule Zahra
- Emily R. Hudson
- Umesh C. Sharma
Institutions
- VA Western New York Healthcare System (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1161/jaha.125.046414
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00