Enablers and barriers to participation in vaccine trials: a narrative synthesis
Vaccine trial participation is shaped by a dynamic risk-benefit calculus that manifests differently across populations. Addressing inequities requires sustained community partnerships, culturally competent trial design, proportionate material support, and proactive communication strategies to counter misinformation. These findings provide actionable guidance for designing more inclusive vaccine trials.
Authors
- Maheshi Ramasamy (ORCID: https://orcid.org/0000-0002-2119-951X)
- Nasima Miah
- Carol Akroyd
- Michelle A. Prendergast
- Eva P. Galiza (ORCID: https://orcid.org/0000-0002-2653-6079)
- Tracey Bingham
- Atreya Ramanan
- Michal Chantkowski
- Saul N. Faust (ORCID: https://orcid.org/0000-0003-3410-7642)
- Georgina Nakafero (ORCID: https://orcid.org/0000-0002-3859-7354)
- Hannah L. Brooks (ORCID: https://orcid.org/0000-0002-5400-3755)
- Nadia Daniel
- Denis Murphy
- Kamlesh Khunti
- Milena Mejia
- Christina Milton
- Susan Owera
- Ravinder Kundra
- Deanna Rex
- Christine Smith
- Sophia Wilkinson
- Gurdeep Kaur
- Monira Ahmed Chowdhury
Institutions
- University of Nottingham (GB)
- University of Leicester (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Vaccine
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1016/j.vaccine.2025.128183
- Primary Topic
- Vaccine Coverage and Hesitancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care