LAPTM5 drives omental metastasis in high-grade serous ovarian cancer via TGF-β/Smad-mediated epithelial plasticity
These findings identify LAPTM5 as a key regulator of TGF-β/Smad-driven epithelial plasticity and omental dissemination in HGSOC, positioning it as both a prognostic biomarker and a potential therapeutic target for advanced-stage disease.
Authors
- Jin Q. Cheng (ORCID: https://orcid.org/0000-0003-1473-7807)
- Yan Gao (ORCID: https://orcid.org/0000-0003-2067-8241)
- Zhefeng Li
- Jie Li
- Wentao Yue
- Lisha Hou
- Mei Jiang
- Chenghong Yin
- Xiaoyang Han
Institutions
- Beijing Friendship Hospital (CN)
- Beijing Obstetrics and Gynecology Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1186/s12967-025-07319-z
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00