Molecular Characterization of Linezolid-Non-Susceptible Enterococcus faecium: Identification of optrA and vanM Co-Harboring Strain in Clinical Isolate from China

This study identified key notable findings in LNSEFM: identification of linezolid intermediate VRE in China, clinical detection of the <i>optrA</i> KLDK variant in enterococci, <i>optrA-vanM</i> co-presence in vancomycin-susceptible <i>E. faecium</i>, and a novel sequence type (ST2709). These findings enrich our understanding of the molecular epidemiology of LNSEFM and provide critical insights into clinical antimicrobial management and infection control.