Efficacy of NSAIDs and corticosteroids as premedication for post-endodontic pain management: A systematic review and meta-analysis

Both NSAIDs and corticosteroids are effective preemptive agents for managing post-endodontic pain in symptomatic irreversible pulpitis. NSAIDs should be preferred for rapid early relief, while corticosteroids provide extended analgesia. Findings highlight their opioid-sparing potential and support their inclusion in evidence-based endodontic pain management protocols. Further multicenter RCTs are warranted to refine patient-tailored regimens.