Organophotocatalytic Radical Cascade Cyclization To Access 2-Trifluoromethylthiolated Quinoline Derivatives

The quinoline skeleton is commonly found in active molecules, making its synthesis a major focus of the ongoing research. This study presents a photoinduced strategy for synthesizing 2-trifluoromethylthiolated quinoline derivatives. This one-pot process involves a radical cascade cyclization between 1-isocyano-2-vinylbenzenes and Phth-SCF₃. Notably, the transformation proceeds in the absence of transition metals or oxidants and shows excellent chemoselectivity and broad functional group compatibility.