Effect of siRNA-mediated LGR5 Inhibition on the Expression of Stemness-related Genes in Triple-negative Breast Cancer Spheroid Model
In summary, the results indicated that <i>LGR5</i> suppression is effective in reducing stemness-related genes and may be considered a good candidate for combination therapy along with chemotherapy.
Authors
- Sepideh Ghobakhloo (ORCID: https://orcid.org/0009-0003-0325-1868)
- Reza Nedaeinia (ORCID: https://orcid.org/0000-0001-9922-7181)
- Sima Jafarpour (ORCID: https://orcid.org/0000-0002-2303-1198)
- Rasoul Salehi
Institutions
- Isfahan University of Medical Sciences (IR)
Publication Details
- Journal
- Advanced Biomedical Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.4103/abr.abr_124_24
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00