Study on the Synthesis and Structure-activity Relationship of 3-Styrylflavones Possessing Variously Hydroxylated D-ring Moiety

The introduction of a hydroxyl group in 3-styryl substituent of 3-styrylflavone greatly increased the antiproliferative activity. Structure-activity relationship studies clearly indicated the importance of the hydroquinone structure as the D-ring moiety and suggested the possibility that the 3-styrylflavones possessing hydroquinone-type D-ring moiety act as "mitocan".