Comparative Analysis of Equivocal (2+) and Positive (3+) HER2 Immunohistochemistry (IHC) and Bright-Field Dual-Color In Situ Hybridization (DISH) in Primary Breast Cancer From 1,307 Node-Positive Patients

Our study demonstrates a high concordant rate between HER2 IHC and DISH in the IHC 3+ group and a low positive rate in the IHC 2+ group. We found no significant difference in the positive rates of HER2 IHC to DISH when compared with prior data of IHC to FISH, reaffirming the use of HER2 DISH as an effective and more accessible alternative to FISH in HER2 2+/3+ breast cancer.

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Publication Details

Journal
Breast Cancer Basic and Clinical Research
Published
2025-12-01
DOI
https://doi.org/10.1177/11782234251407914
Primary Topic
HER2/EGFR in Cancer Research
Type
article
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article

Comparative Analysis of Equivocal (2+) and Positive (3+) HER2 Immunohistochemistry (IHC) and Bright-Field Dual-Color In Situ Hybridization (DISH) in Primary Breast Cancer From 1,307 Node-Positive Patients

Kroonpong Iampenkhae, Sompon Apornvirat, Adiluck Pisutpunya, Chawinthorn Vuthithammee et al.
Breast Cancer Basic and Clinical Research
HER2/EGFR in Cancer Research
article

Comparative Analysis of Equivocal (2+) and Positive (3+) HER2 Immunohistochemistry (IHC) and Bright-Field Dual-Color In Situ Hybridization (DISH) in Primary Breast Cancer From 1,307 Node-Positive Patients

Kroonpong Iampenkhae, Sompon Apornvirat, Adiluck Pisutpunya, Chawinthorn Vuthithammee, Piyakawin Sodsoon
article en

Abstract

Our study demonstrates a high concordant rate between HER2 IHC and DISH in the IHC 3+ group and a low positive rate in the IHC 2+ group. We found no significant difference in the positive rates of HER2 IHC to DISH when compared with prior data of IHC to FISH, reaffirming the use of HER2 DISH as an effective and more accessible alternative to FISH in HER2 2+/3+ breast cancer.

Breast Cancer Basic and Clinical ResearchVol. 19
Thammasat University (TH), Thai Red Cross Society (TH), Chulalongkorn University (TH), King Chulalongkorn Memorial Hospital (TH)
Openalex Percentile: Top 30%
HER2/EGFR in Cancer Research
DOIOpen Access PDFOpenAlex
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Comparative Analysis of Equivocal (2+) and Positive (3+) HER2 Immunohistochemistry (IHC) and Bright-Field Dual-Color In Situ Hybridization (DISH) in Primary Breast Cancer From 1,307 Node-Positive Patients — Kroonpong Iampenkhae, Sompon Apornvirat, et al. · Breast Cancer Basic and Clinical Research (2025) | TGRS Research Map | TGRS