Safety and efficacy of IL-23 inhibitors in patients with moderate to severe ulcerative colitis: a systematic review and meta-analysis of randomized controlled trials
IL-23 inhibitors provide significant improvements in clinical remission and mucosal healing, with a favorable safety profile, particularly during induction therapy in moderate to severe UC.
Authors
- Alveera Hasan (ORCID: https://orcid.org/0000-0002-9481-9142)
- Syed Anjum Gardezi (ORCID: https://orcid.org/0000-0002-7653-7061)
- Sundas Hasan (ORCID: https://orcid.org/0000-0001-9704-3135)
- Salman Majeed
- Maryam Shahzad (ORCID: https://orcid.org/0009-0002-3565-8358)
- Qutaiba Albustanji
- Mushood Ahmed (ORCID: https://orcid.org/0000-0001-9872-8224)
- Hamza Amin
- Maheen Sattar Shoaib
- Humza Sadique
- Raheel Ahmed
- Rachel Lilley
- Arif Atique
- Muhammad Aamir Shahzad
- Reem Abukhater
- Saad Muhammad Khalid
Institutions
- Rawalpindi Medical University (PK)
- Jinnah Sindh Medical University (PK)
- Middlesbrough College (GB)
- University Hospitals of Leicester NHS Trust (GB)
- South Tees Hospitals NHS Foundation Trust (GB)
- Dow University of Health Sciences (PK)
- Northampton General Hospital NHS Trust (GB)
- Specialty Hospital, Jordan (JO)
- South Tyneside and Sunderland NHS Foundation Trust (GB)
- Shrewsbury and Telford Hospital NHS Trust (GB)
- South Warwickshire NHS Foundation Trust (GB)
- Imperial College London (GB)
- Ras al-Khaimah Medical and Health Sciences University (AE)
Publication Details
- Journal
- International Journal of Colorectal Disease
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1007/s00384-025-05014-5
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00