Primary Gastrointestinal B-Cell Lymphomas: A Clinicopathological Review

The gastrointestinal tract is the most frequent extranodal site for lymphomas. Primary gastrointestinal B-cell lymphomas represent a distinct group of lymphoproliferative disorders and are the most common type of gastrointestinal lymphomas. Their pathogenesis, clinicopathological characteristics, and prognosis may differ from their nodal or systemic counterparts, emphasizing the importance of accurately identifying them. This review incorporates some of the latest literature on common primary gastrointestinal B-cell lymphomas focusing on their unique pathogenic mechanisms, clinical features, and pathological findings. It also addresses the prognostic outcomes associated with these lymphomas and provides a brief overview of the available treatment options.