Fibroblast growth factor 9 activates fibroblast activation and drives the progress of shoulder stiffness
Our findings revealed that FGF9 drove fibroblast activation and joint capsule fibrosis in SS via the PI3K/Akt signaling pathway. Targeted inhibition of the PI3K/Akt signaling might represent a promising therapeutic strategy for SS.
Authors
- Weihan Yu
- Y. Liu
- Beijie Qi (ORCID: https://orcid.org/0000-0002-4041-0050)
- Yunkang Kang (ORCID: https://orcid.org/0009-0001-2740-4924)
- Biao Guo
- Wenzhi Bi
- Haiyang Yu
- Jian Xu
- Dongqiang Yang
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Fuyang Maternity and Child Health Care Hospital (CN)
- Pudong Medical Center (CN)
- Shanghai First People's Hospital (CN)
- Fuyang Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-12-30
- DOI
- https://doi.org/10.3389/fcell.2025.1731453
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00