Immunohistochemical study of Rho-kinase pathway expression in a mouse model of prostate hypertrophy for preliminary study of progressive prostate cancer model establishment

For our establishment of a prostate cancer model for mice, our <i>in vivo</i> experiments using IHC study demonstrated that the overexpression of α-1 adrenoceptor (prostate enlargement), β-3 adrenoceptor and Rho-kinase (bladder) biomarkers indicated that prostate enlargement can cause bladder muscle atrophy. Further research could be undertaken using this prostate enlargement model for cancer research.