Haploinsufficiency of Endothelial Nitric Oxide Synthase Mitigates Beneficial Effects of Maternal Exercise on Fetal Heart Development During Pregestational Diabetes
Maternal exercise does not prevent CHDs in PGD offspring of eNOS<sup>+/-</sup> mice. Its ability to mitigate PGD-induced oxidative stress is eNOS dependent and essential for improving heart morphology.
Authors
- Ryleigh van Neck
- Xiangru Lu
- Lambertus J. Wisse
- Marco C. DeRuiter (ORCID: https://orcid.org/0000-0002-0528-7464)
- Qingping Feng
- Thomas Pan
- Ivana Du
Institutions
- Western University (CA)
- Leiden University Medical Center (NL)
- London Health Sciences Centre (CA)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1161/jaha.125.042848
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00