Outcomes of Hematopoietic Stem Cell Transplantation Following the Use of Blinatumomab in Pediatric Relapsed B-Cell Acute Lymphoblastic Leukemia: A Single-Center Experience

In this single-center experience from a low-/middle-income country (LMIC), blinatumomab served as an effective bridge to HSCT, enabling MRD-negative remissions with favorable post-transplant outcomes. Viral reactivations and steroid-refractory GVHD were reported, underlining the need for robust surveillance. Broader access to blinatumomab and prospective studies are needed to validate these findings and to evaluate cost-effectiveness in LMICs.

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Publication Details

Journal
Journal of Hematology
Published
2025-12-01
DOI
https://doi.org/10.14740/jh2132
Primary Topic
Acute Lymphoblastic Leukemia research
Type
article
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article

Outcomes of Hematopoietic Stem Cell Transplantation Following the Use of Blinatumomab in Pediatric Relapsed B-Cell Acute Lymphoblastic Leukemia: A Single-Center Experience

Anukriti Srivastava, Hari Gaire, Nita Radhakrishnan, Sudipto Bhattacharya et al.
Journal of Hematology
Acute Lymphoblastic Leukemia research
article

Outcomes of Hematopoietic Stem Cell Transplantation Following the Use of Blinatumomab in Pediatric Relapsed B-Cell Acute Lymphoblastic Leukemia: A Single-Center Experience

Anukriti Srivastava, Hari Gaire, Nita Radhakrishnan, Sudipto Bhattacharya, Aditi Tulsiyan, Anuj Singh
article en

Abstract

In this single-center experience from a low-/middle-income country (LMIC), blinatumomab served as an effective bridge to HSCT, enabling MRD-negative remissions with favorable post-transplant outcomes. Viral reactivations and steroid-refractory GVHD were reported, underlining the need for robust surveillance. Broader access to blinatumomab and prospective studies are needed to validate these findings and to evaluate cost-effectiveness in LMICs.

Journal of HematologyVol. 14(6)
Institute of Child Health (IN), Institute of Cytology and Preventive Oncology (IN)
No poverty
Openalex Percentile: Top 25%
Acute Lymphoblastic Leukemia research
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