Adjunctive Use of LASER in The Management of Desquamative Lesions: A Case Series

Abstract Auto-immune disorders result from an exaggerated immune response damaging organs and tissues due to genetic predisposition and environmental triggers. They may effect the oral cavity and commonly manifest as oral lichen planus, mucous membrane pemphigoid, pemphigus vulgaris and epidermolysis bullosa acquisita . Oral manifestations can serve as early indicators of broader immunological problems. Symptoms involve changes such as thickened lines of redness, blisters, erosion, and ulcers, often occurring on the tongue, buccal mucosa, and gingiva. Current treatments for desquamative lesions focus on general disease symptoms and involve topical corticosteroids, immunosuppressants, and antibiotics, but systemic steroid usage carries notable risks. As an alternative, low-level laser therapy (LLLT) has emerged as promising modality, offering anti-inflammatory effects, pain relief, and tissue regeneration without the drawbacks of traditional medications. Case series This case series demonstrates the effects of three different modalities of lasers (Laser ablation, PBM and PDT) in gingival lesions caused by autoimmune diseases like oral lichen planus, Pemphigus vulgaris and epidermolysis bullosa, potentially providing a safer and effective therapeutic option as an adjunct to topical steroids Conclusion: The outcome in our cases suggests that the use of LASER in the management of desquamative lesions had a beneficial effect which included increased steroid free period, improved patient reported outcome measures, improved patient reported experience measures.