Bacteriological Profile and Antimicrobial Resistance in Intraoperative Purulent Samples From Acute Appendicitis: A 3‐Year Retrospective Analysis

Gram-negative enteric bacteria, particularly E. coli, are the dominant pathogens in appendiceal infections. Carbapenems and amikacin retain excellent efficacy, whereas amoxicillin and several commonly used antibiotics show poor activity. Piperacillin-tazobactam represents a reasonable first-line empirical choice, while carbapenems should be reserved for severe infections or patients at risk for resistant organisms. These findings highlight the importance of local resistance surveillance to guide institution-specific antibiotic protocols.