Assessing glymphatic function in schizophrenia and mood disorders: Insights from a diffusion tensor image along the perivascular space ( <scp>DTI</scp> ‐ <scp>ALPS</scp> ) and neuroanatomical correlations
The ALPS index may reflect glymphatic dysfunction across psychiatric disorders and relate to brain structure and clinical characteristics. These findings support its potential as an indirect biomarker of neurobiological alterations. Further research using direct glymphatic imaging is needed to clarify the mechanistic role of glymphatic function in psychiatric disorders.
Authors
- Ding‐Lieh Liao (ORCID: https://orcid.org/0000-0002-2192-7273)
- Chengyi Huang (ORCID: https://orcid.org/0000-0001-8093-816X)
- Shih‐Jen Tsai (ORCID: https://orcid.org/0000-0002-9987-022X)
- Jun‐Ding Zhu (ORCID: https://orcid.org/0000-0003-0718-4087)
- Albert C. Yang (ORCID: https://orcid.org/0000-0003-2794-9649)
- Hsin‐I. Chang
- Chiung‐Chih Chang (ORCID: https://orcid.org/0000-0002-6721-2556)
- Ching‐Po Lin
- Hsin‐Jung Tsai
Institutions
- National Yang Ming Chiao Tung University (TW)
- Taipei Veterans General Hospital (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Chung Shan Medical University Hospital (TW)
- Bali Psychiatric Center (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Psychiatry and Clinical Neurosciences
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1111/pcn.70016
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00