Cardiovascular Risk as a Moderator of the Relationship Between Plasma Alzheimer Disease Biomarkers and Cognitive Status
Plasma AD biomarkers and cardiovascular risk were independently associated with cognitive status, with cardiovascular risk moderating the p-tau181 and p-tau217 cognitive status relationships. If certain plasma biomarkers and cardiovascular risk independently contribute to dementia risk, cardiovascular risk assessment should complement other biomarker evaluations in cognitive screening. Results should be interpreted with caution as associations might be primarily driven by age and sex. Future research including education and genetic risk is needed to clarify the studied relationships.
Authors
- Lynne Hughes
- Ivan Koychev (ORCID: https://orcid.org/0000-0001-6813-8493)
- Benjamin Tari (ORCID: https://orcid.org/0000-0003-3751-3179)
- Daniela Jaime García (ORCID: https://orcid.org/0000-0002-9457-9855)
- Angelina Kancheva (ORCID: https://orcid.org/0000-0002-0077-3543)
- Ivana Kancheva (ORCID: https://orcid.org/0000-0002-1151-6243)
- D. Lyall
- Terence J. Quinn (ORCID: https://orcid.org/0000-0003-1401-0181)
- Kalliopi Mavromati (ORCID: https://orcid.org/0000-0002-6600-064X)
- Kamen A. Tsvetanov (ORCID: https://orcid.org/0000-0002-3178-6363)
- Joanna M. Wardlaw
Institutions
- University of Cambridge (GB)
- Leiden University Medical Center (NL)
- University of Oxford (GB)
- Global Alzheimer's Platform Foundation (US)
- University College London (GB)
- Imperial College London (GB)
- University of Glasgow (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1161/jaha.125.044438
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00