Upregulation of miR-502-5p in traumatic spinal cord injury modulates neuroinflammation and oxidative stress by targeting FBXO28
MiR-502-5p shows promise as a biomarker for SCI, with its expression closely associated with injury severity. Mechanistically, it appears to facilitate the progression of SCI by directly targeting FBXO28, thereby exacerbating neuronal apoptosis, inflammatory responses, and oxidative stress.
Authors
- Di Qiu (ORCID: https://orcid.org/0000-0003-0325-6813)
- Jinxiang Zhang
- Xintong Hao
- Juanyu Liu
Institutions
- Xuzhou Medical College (CN)
- University of Malaya (MY)
- Wuhan No.1 Hospital (CN)
- Wuhan No. 7 Hospital (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Wuhan No.9 Hospital (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1186/s13018-025-06565-7
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00