Radiotherapy vs. photodynamic therapy: a comparison of antitumor effects and pulmonary toxicity in preclinical models
Despite the differences in dose delivery between RTx and PDT, PDT demonstrated comparable antitumor efficacy to RTx in mouse xenograft model and a safer pulmonary toxicity profile than RTx in rat ILD model. PDT is possibly a promising treatment modality for lung cancer associated with ILD.
Authors
- Masato Aragaki (ORCID: https://orcid.org/0000-0002-2943-764X)
- Fumi Yokote (ORCID: https://orcid.org/0000-0002-1903-6631)
- Y Fujibayashi (ORCID: https://orcid.org/0000-0002-9240-6651)
- Akira Saito (ORCID: https://orcid.org/0000-0003-3859-5575)
- Takahiro Yanagihara (ORCID: https://orcid.org/0000-0001-5047-6558)
- Liang Ding (ORCID: https://orcid.org/0000-0002-3047-9556)
- J. Chen
- Jonathan Yeung (ORCID: https://orcid.org/0000-0001-5759-3028)
- Gang Zheng (ORCID: https://orcid.org/0000-0002-5721-4072)
- Tsukasa Ishiwata (ORCID: https://orcid.org/0000-0003-2369-2698)
- Andrew Effat (ORCID: https://orcid.org/0000-0002-1533-3241)
- Yoshihisa Hiraishi (ORCID: https://orcid.org/0000-0003-3926-9245)
- Nicholas Bernards (ORCID: https://orcid.org/0009-0007-7907-0317)
- T. Koga (ORCID: https://orcid.org/0000-0002-3488-1833)
- Hiroyuki Ogawa
- Jonathan Allen
- K Yasufuku
- Kate Kazlovich
- Nadia Mohammed
- Hidenori Kage
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Toronto General Hospital (CA)
- The University of Tokyo (JP)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.21037/tlcr-2025-662
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00