Clinical and Molecular Differences of Hypertensive Disorders During Pregnancy
Our findings suggest that maternal vascular malperfusion specifically differentiates pregnancies that progress to PE and siPE. Maternal vascular malperfusion is thought to initiate in early gestation, indicating the cascade to PE/siPE may be differentiated from gHTN/cHTN early in pregnancy. Incorporating placental histopathologic evaluation is an essential future avenue in probing the etiology of HDP.
Authors
- Omonigho Aisagbonhi (ORCID: https://orcid.org/0000-0001-7855-8619)
- Mariko Horii (ORCID: https://orcid.org/0000-0002-4996-6792)
- Jennifer N. Chousal (ORCID: https://orcid.org/0000-0002-8725-6142)
- Tzu Ning Liu (ORCID: https://orcid.org/0000-0003-1443-9391)
- Morgan Meads (ORCID: https://orcid.org/0000-0002-5970-7356)
- Sierra Adkins (ORCID: https://orcid.org/0009-0009-5496-022X)
- Robert Morey (ORCID: https://orcid.org/0000-0001-8480-4564)
- Abbas Hakim
- Marni B Jacobs
- Anushka Ranjeet Edlabadkar
- Leah Lamale-Smith
- Valentina Stanley
- Samantha La Belle
- Richard B. Wolf
Institutions
- MACOM (United States) (US)
- University of California System (US)
- University of California San Diego (US)
- Sanford Consortium for Regenerative Medicine (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1161/atvbaha.125.323457
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00