Transcatheter Aortic Valve Replacement in a Patient with Ankylosing Spondylitis and Complex Valvulopathy: Managing Aortic Regurgitation, Mitral Regurgitation, and Ventricular Arrhythmias

Complex cardiac damage caused by ankylosing spondylitis (AS) is relatively rare in clinical practice. Although the first clear association between AS and aortic regurgitation (AR) was established in 1958, and subsequent case reports have been published, previous studies have not proposed effective, minimally invasive surgical treatment options. This report describes a patient with AS, AR, and mitral regurgitation who experienced frequent premature ventricular contractions, posing an extremely high risk of sudden death. We used a combination of multimodal imaging techniques to perform transcatheter aortic valve replacement on the patient. The patient recovered well after the procedure, with improved cardiac function. This case serves as a reference for treating patients with similar conditions.