Andrographolide Induces Mitochondrial Dysfunction and Alters Stemness-related Gene Expression in MCF7 Breast Cancer Cells
Andrographolide exerts anti-cancer effects through mitochondrial dysfunction and apoptosis, while paradoxically increases OCT4 expression. These findings may indicate an adaptive cellular survival mechanism, in which OCT4 up-regulation and TOMM20 down-regulation are correlated with cancer-like characteristics.
Authors
- Ruttachuk Rungsiwiwut (ORCID: https://orcid.org/0000-0002-1448-2309)
- Ramida Watanapokasin (ORCID: https://orcid.org/0000-0001-8333-3238)
- Sasipat Teerawongsuwan
- Sirinya Jenjittikul
- YOVIPAT SENAWEENIN
- NATTHIMA SUWAN
Institutions
- Srinakharinwirot University (TH)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-12-30
- DOI
- https://doi.org/10.21873/anticanres.17940
- Primary Topic
- Andrographolide Research and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00