Inhibitory Effect of Sirtuin6 on EndMT by Regulating Oxidative Stress and Autophagy in Coxsackievirus B3‐Induced Cardiac Endothelial Cells
This study reveals that Sirt6 inhibits CVB3-induced EndMT by regulating oxidative stress and autophagy. These findings provide experimental evidence for elucidating the pathological mechanisms of VMC and suggest Sirt6 as a potential therapeutic target.
Authors
- Xinyang Shou (ORCID: https://orcid.org/0000-0002-8304-9576)
- Di Zhang (ORCID: https://orcid.org/0000-0001-6888-201X)
- Zimei Yang
- Zhidong Zhou (ORCID: https://orcid.org/0009-0005-2380-5885)
- Jun Chen
- Yimin Wang
- Qiang Liu
Institutions
- The Third Affiliated Hospital of Zhejiang Chinese Medical University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/iid3.70316
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences