The treatment of acute tendon injury with small extracellular vesicles originating from TNFAIP6− ADSCs subpopoulation both in vitro and in vivo
Our findings enhance the current understanding of how TNFAIP6<sup>-</sup> ADSC-sEVs exert healing properties in acute tendon injury through the let-7c-5p/CRCT1/JAK2/STAT3 signaling pathway. Furthermore, this study proposes a concept for constructing conditional ADSC-sEVs to enhance their inherent therapeutic effects.
Authors
- QingBo Cui
- HengChen Liu
- Zenan Zhang (ORCID: https://orcid.org/0000-0001-5796-4159)
- Wenjun Lu (ORCID: https://orcid.org/0000-0001-5789-9959)
- Tingting Zhang (ORCID: https://orcid.org/0000-0002-6600-9791)
- Yue Wu (ORCID: https://orcid.org/0000-0002-9073-5988)
- Zhaozhu Li
- Yibo Miao
- Jingyao Zhang (ORCID: https://orcid.org/0000-0002-8227-9396)
- Limin Hou
- Shuyao Wang
- Mingzhao Zhang
- Manyu Shi
- Aodan Zhang
Institutions
- Harbin Medical University (CN)
- Xiamen University (CN)
- Anhui Medical University (CN)
- Westlake University (CN)
- Zhejiang Cancer Hospital (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Ministry of Education (IR)
- Children's Hospital of Zhejiang University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1186/s13287-025-04789-2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00