NF1-Specific Growth Charts for Head Circumference Over the First 3 Years of Life
We present the first NF1-specific growth charts for head circumference covering the age range of 0-3 years. Macrocephaly in NF1 becomes more exaggerated over time as rate of growth is sustained compared with controls. Smaller head size relative to NF1 growth expectations is not captured by CDC charts yet it nevertheless relates to developmental delay, suggesting that NF1-specific charts may increase sensitivity to clinically concerning patterns of growth in children with NF1.
Authors
- Michael J. Fisher (ORCID: https://orcid.org/0000-0003-3408-3839)
- W. Spencer Guthrie (ORCID: https://orcid.org/0000-0001-5529-1050)
- Jonathan M. Payne (ORCID: https://orcid.org/0000-0001-9565-3845)
- Shruti Garg (ORCID: https://orcid.org/0000-0002-4472-4583)
- Ayan S. Mandal (ORCID: https://orcid.org/0000-0002-0780-3864)
- Matthew C. Hocking (ORCID: https://orcid.org/0000-0002-1368-0856)
- Kathryn N. North (ORCID: https://orcid.org/0000-0003-0841-8009)
- Benjamin Jung (ORCID: https://orcid.org/0000-0001-8994-0506)
- Margaret Gardner (ORCID: https://orcid.org/0000-0002-4498-0827)
- Benjamin E. Yerys (ORCID: https://orcid.org/0000-0002-7370-0740)
- John D. Herrington (ORCID: https://orcid.org/0000-0002-9720-3917)
- Gareth Ball (ORCID: https://orcid.org/0000-0003-3509-1435)
- Jakob Seidlitz (ORCID: https://orcid.org/0000-0002-8164-7476)
- Karen Jaqueline Low (ORCID: https://orcid.org/0000-0002-4975-9363)
- Kelly M. Janke
- Tim J. Cole (ORCID: https://orcid.org/0000-0001-5711-8200)
- Aaron Alexander-Bloch (ORCID: https://orcid.org/0000-0003-0055-1518)
- Russell T. Shinohara
- Habib Elias Akouri
- Nils Muhlert
Institutions
- North Bristol NHS Trust (GB)
- Children's Hospital of Philadelphia (US)
- Greater Manchester Mental Health NHS Foundation Trust (GB)
- The University of Melbourne (AU)
- Great Ormond Street Hospital (GB)
- University of Manchester (GB)
- University of Bristol (GB)
- Manchester University NHS Foundation Trust (GB)
- Murdoch Children's Research Institute (AU)
- University College London (GB)
- University of Pennsylvania (US)
- Philadelphia University (US)
- Center for Autism and Related Disorders (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1212/wnl.0000000000214480
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 0.00