IFNL4-rs12979860 CC genotype predisposes to accelerated terminal exhaustion and senescence in HIV/HCV-chronic infection
CC-carriage may result in premature cellular activation and senescence or impaired functionality during HCV chronic infection in PWH, which may be masked by their maintained plasma immune homeostasis during clinical monitoring.
Authors
- Verónica Briz (ORCID: https://orcid.org/0000-0003-2297-5098)
- Sonia Arca-Lafuente (ORCID: https://orcid.org/0000-0003-4750-0988)
- Amanda Fernández-Rodríguez
- Pablo Ryan (ORCID: https://orcid.org/0000-0002-4212-7419)
- Andrés Deza de la Casa
- Luz Martín-Carbonero
- Ignacio de los Santos
- Violeta Lara-Aguilar
- Mariano Matarranz
- Manuel Llamas-Adán
- Sergio Grande-García
- Mª Ángeles Jiménez-Sousa
Institutions
- Hospital Universitario La Paz (ES)
- Instituto de Salud Carlos III (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Universitario de La Princesa (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Hospital Universitario Infanta Leonor (ES)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1186/s12967-025-07070-5
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia e Innovación
- European Regional Development Fund
- Agencia Estatal de Investigación