Accelerated Brain Aging, Atherogenicity, and Neurocognition in Adult Survivors of Childhood Cancer
This cross-sectional study found that accelerated brain aging was associated with poorer neurocognitive outcomes and correlated with cranial radiation, biomarkers of atherogenesis, neuronal damage, and sex hormone precursors. These findings can guide future research efforts to reduce the risk of vascular disease in this at-risk population.
Authors
- Silu Zhang
- AnnaLynn M. Williams (ORCID: https://orcid.org/0000-0002-7042-5851)
- Meenasri Kumbaji (ORCID: https://orcid.org/0000-0002-0192-8420)
- Matthew Scoggins (ORCID: https://orcid.org/0000-0003-1783-4274)
- Yutaka Yasui (ORCID: https://orcid.org/0000-0002-6117-4990)
- K. K. Ness
- Jessica L. Baedke (ORCID: https://orcid.org/0000-0001-5085-4985)
- Nicholas S. Phillips (ORCID: https://orcid.org/0000-0002-2021-4036)
- Ruth Tatevossian (ORCID: https://orcid.org/0000-0002-1653-3026)
- Noah D. Sabin (ORCID: https://orcid.org/0000-0002-7584-2574)
- Kevin R. Krull (ORCID: https://orcid.org/0000-0002-0476-7001)
- Qing Ji (ORCID: https://orcid.org/0000-0002-2466-9193)
- Sebabrata Mahapatra
- Melissa M. Hudson
Institutions
- St. Jude Children's Research Hospital (US)
- University of Rochester Medical Center (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.51865
- Primary Topic
- Childhood Cancer Survivors' Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Cancer Institute