Development and Validation of a Simultaneous Quantification Method for 12 Targeted Therapies and 3 Active Metabolites in Human Plasma Using Liquid Chromatography–Tandem Mass Spectrometry: An Application to Therapeutic Drug Monitoring in Patients With
We developed and validated a sensitive liquid chromatography-tandem mass spectrometry method requiring only 50 µL of plasma volume for the quantification of 12 targeted oral anticancer drugs and 3 active metabolites. This multianalyte assay offers strong potential for TDM in patients receiving contemporary anticancer treatments.
Authors
- N. Vignal (ORCID: https://orcid.org/0000-0002-4833-2763)
- Samia Mourah (ORCID: https://orcid.org/0000-0002-9283-1068)
- Lauriane Goldwirt (ORCID: https://orcid.org/0000-0001-9741-803X)
- Sofiane Fodil (ORCID: https://orcid.org/0000-0002-6713-1609)
- Hélène Sauvageon
- Delphine Réa (ORCID: https://orcid.org/0000-0001-5379-7461)
- Alain Plé
- Nicolas Etienne (ORCID: https://orcid.org/0000-0002-3926-6215)
- Marie Allard
- Marie Sébert
Institutions
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Saint-Louis (FR)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1097/ftd.0000000000001426
- Primary Topic
- Biosimilars and Bioanalytical Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00