Prevalence of Novel and Recurrent Pathogenic Variants in BRCA Genes in a Cohort of Iranian Hereditary Breast Cancer Patients

Young age at onset and having a positive family history of cancer are among the most important criteria to perform genetic testing. Identification of the carriers of pathogenic variants in high-risk families and also recurrent variants in the population will contribute to prevent of HBC.

Authors

Akram Sarmadi (ORCID: https://orcid.org/0000-0002-6669-6990)
Shaghayegh Haghjooy Javanmard
Mehrdad Zeinalian
Majid Hosseinzadeh
Mohammad Amin Tabatabaiefar

Institutions

Isfahan University of Medical Sciences (IR)
Tehran University of Medical Sciences (IR)

Publication Details

Journal: Advanced Biomedical Research
Published: 2025-12-01
DOI: https://doi.org/10.4103/abr.abr_681_24
Primary Topic: BRCA gene mutations in cancer
Type: article
Field-Weighted Citation Impact: 0.00

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article

Prevalence of Novel and Recurrent Pathogenic Variants in BRCA Genes in a Cohort of Iranian Hereditary Breast Cancer Patients

Akram Sarmadi, Shaghayegh Haghjooy Javanmard, Mehrdad Zeinalian, Majid Hosseinzadeh et al.

Dec 1, 2025

Advanced Biomedical Research

BRCA gene mutations in cancer

article

Prevalence of Novel and Recurrent Pathogenic Variants in BRCA Genes in a Cohort of Iranian Hereditary Breast Cancer Patients

Akram Sarmadi, Shaghayegh Haghjooy Javanmard, Mehrdad Zeinalian, Majid Hosseinzadeh, Mohammad Amin Tabatabaiefar

December 1, 2025article en

Abstract

Young age at onset and having a positive family history of cancer are among the most important criteria to perform genetic testing. Identification of the carriers of pathogenic variants in high-risk families and also recurrent variants in the population will contribute to prevent of HBC.

Advanced Biomedical ResearchVol. 14(1)

Isfahan University of Medical Sciences (IR), Tehran University of Medical Sciences (IR)

Openalex Percentile: Top 24%

BRCA gene mutations in cancer

DOI Open Access PDF OpenAlex

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