Inflammatory bowel disease (IBD) is associated with increased intestinal extrachromosomal circular DNA: an emerging biomarker for IBD type and activity
Here, we uncover an IBD-specific pattern of eccDNA production from intestinal biopsies. Furthermore, we have identified genic hotspots that characterize active disease. We propose that eccDNA containing specific gene fragments (eg, NRG1 and ZPMF2) could represent a promising new biomarker tool for patients with IBD.
Authors
- Letizia Masi (ORCID: https://orcid.org/0000-0002-8251-7358)
- Antonia Piazzesi (ORCID: https://orcid.org/0000-0002-7591-6473)
- V. Emoli (ORCID: https://orcid.org/0000-0003-0593-9327)
- Maria Cristina Giustiniani (ORCID: https://orcid.org/0000-0003-1649-3738)
- Valentina Petito (ORCID: https://orcid.org/0000-0003-4396-1613)
- Alessandra Russo (ORCID: https://orcid.org/0000-0002-3318-8711)
- Elisabetta Tabolacci (ORCID: https://orcid.org/0000-0002-4707-2242)
- Loris Riccardo Lopetuso (ORCID: https://orcid.org/0000-0002-5747-2055)
- Lucrezia Laterza (ORCID: https://orcid.org/0000-0001-5515-1197)
- Tommaso Mazza (ORCID: https://orcid.org/0000-0003-3105-459X)
- Alfredo Papa
- Antonio Gasbarrini
- Araúzo-Bravo Marcos J.
- Franco Scaldaferri
- Laura Turchini
- Lorenza Putignani
- Daniela Gerovska
- Federica di Vincenzo
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Ikerbasque (ES)
- University of the Basque Country (ES)
- Agostino Gemelli University Polyclinic (IT)
- San Sebastián University (CL)
- Bambino Gesù Children's Hospital (IT)
- Link Campus University (IT)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf237
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00