Network toxicology analysis of hair dye components and their association with breast and bladder cancers

This study employed a network toxicology approach to investigate the potential toxic effects and molecular mechanisms of hair dye components in relation to breast and bladder cancer. By integrating data from multiple databases and performing Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, key targets and pathways were identified. Network and molecular docking analyses revealed that major hair dye chemicals may induce carcinogenesis through xenobiotic metabolism and interact with critical proteins involved in cancer pathways. These findings provide theoretical support for the health risks associated with hair dye exposure and offer insights into potential preventive strategies.