The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear, accessible, and well-structured, rather than the scope of the content, which spans approximately 500 pages. The Concise Guide summarises the key pharmacological properties of around 1900 human drug targets, and nearly 7000 interactions, involving around 4400 ligands. While the content is a substantially condensed version of the more detailed information and links available at the www.guidetopharmacology.org website, the printed guide serves as a permanent, citable, point-in-time record, that remains stable despite ongoing updates to the online database. The full contents of this publication can be found at https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70230. The Concise Guides provide expert-curated recommendations of 'Gold Standard' selective pharmacological tools, available either commercially or as donations, which enable the identification of individual drug targets or families of drug targets. While the Concise Guide offers a more streamlined overview, more comprehensive information, including detailed pharmacological profiles and links to multiple online databases, is available through the Guide to Pharmacology website. The 2025/26 edition of the Concise Guide is based on material current as of mid-2025, and supersedes all previous editions, including the 2023/24 Guide, and earlier Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), and as such provides official IUPHAR classification and nomenclature for human drug targets, where applicable. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. Each section includes nomenclature guidance, concise summaries, information of the best available pharmacological tools, key references, and suggestions for further reading.

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Publication Details

Journal
British Journal of Pharmacology
Published
2025-12-01
DOI
https://doi.org/10.1111/bph.70230
Citations
4
Primary Topic
Receptor Mechanisms and Signaling
Type
article
Field-Weighted Citation Impact
3.22
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article

The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

4 citations
British Journal of Pharmacology
Receptor Mechanisms and Signaling
3.22
article

The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

article en
4 citations

Abstract

The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear, accessible, and well-structured, rather than the scope of the content, which spans approximately 500 pages. The Concise Guide summarises the key pharmacological properties of around 1900 human drug targets, and nearly 7000 interactions, involving around 4400 ligands. While the content is a substantially condensed version of the more detailed information and links available at the www.guidetopharmacology.org website, the printed guide serves as a permanent, citable, point-in-time record, that remains stable despite ongoing updates to the online database. The full contents of this publication can be found at https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70230. The Concise Guides provide expert-curated recommendations of 'Gold Standard' selective pharmacological tools, available either commercially or as donations, which enable the identification of individual drug targets or families of drug targets. While the Concise Guide offers a more streamlined overview, more comprehensive information, including detailed pharmacological profiles and links to multiple online databases, is available through the Guide to Pharmacology website. The 2025/26 edition of the Concise Guide is based on material current as of mid-2025, and supersedes all previous editions, including the 2023/24 Guide, and earlier Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), and as such provides official IUPHAR classification and nomenclature for human drug targets, where applicable. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. Each section includes nomenclature guidance, concise summaries, information of the best available pharmacological tools, key references, and suggestions for further reading.

British Journal of PharmacologyVol. 182(S1)
Semmelweis University (HU), Boston University (US), Leiden University (NL), Uppsala University (SE), Scripps Research Institute (US), University of Copenhagen (DK), University of Iowa (US), Cedars-Sinai Medical Center (US), Centre National de la Recherche Scientifique (FR), University of Tasmania (AU), National Institutes of Health (US), Karolinska University Hospital (SE), University of Helsinki (FI), Université de Sherbrooke (CA), University of Bonn (DE), University of Wisconsin–Madison (US), Janssen (Belgium) (BE), University of Padua (IT), University of Nottingham (GB), Deakin University (AU), Emory University (US), University of Leicester (GB), University of Auckland (NZ), Inserm (FR), University of Liège (BE), Universität Hamburg (DE), The University of Queensland (AU), The University of Melbourne (AU), Queen Mary University of London (GB), Medway School of Pharmacy (GB), University of Calgary (CA), University of New Mexico (US), University of Pittsburgh (US), St Petersburg University (RU), Pfizer (United States) (US), University of Strathclyde (GB), King's College London (GB), Georgetown University (US), University of Basel (CH), University of Toronto (CA), Sanford Burnham Prebys Medical Discovery Institute (US), University of Milan (IT), Durham University (GB), University of Aberdeen (GB), Florida International University (US), Johannes Gutenberg University Mainz (DE), Université de Montpellier (FR), Vanderbilt University (US), University of Ferrara (IT), Medical University of Graz (AT), University of California, Irvine (US), Montana State University (US), University of Cambridge (GB), Florey Institute of Neuroscience and Mental Health (AU), Discovery Institute (US), Georgetown University Medical Center (US), University Hospitals of North Midlands NHS Trust (GB), Rhode Island Hospital (US), The Francis Crick Institute (GB), LabCorp (United States) (US), Harvard University Press (US), King Saud University (SA), Karolinska Institutet (SE), University of Manchester (GB), UNSW Sydney (AU), Maastricht University (NL), University of Bristol (GB), University of California San Diego (US), Cleveland Clinic Lerner College of Medicine (US), California University of Pennsylvania (US), Centre de Gestion Scientifique (FR), Office of the Director (US), Novaliq (Germany) (DE), University Medical Center of the Johannes Gutenberg University Mainz (DE), Indiana State University Foundation (US), Max Planck Institute for Heart and Lung Research (DE), National Institute of Nursing Research (US), Chinese University of Hong Kong, Shenzhen (CN), Source BioScience (United Kingdom) (GB), Hitchin Hospital (GB), Takeda (United States) (US), Janssen (United States) (US), National Institutes of Health Clinical Center (US), Redx Pharma (United Kingdom) (GB), Ehime University (JP), University College London (GB), Novartis Foundation (CH), University of Córdoba (ES), University of Bari Aldo Moro (IT), Keele University (GB), Monash University (AU), Monash Institute of Medical Research (AU), Université de Rouen Normandie (FR), Technical University of Munich (DE), University at Buffalo, State University of New York (US), Florida Atlantic University (US), University of Milano-Bicocca (IT), Université de Montréal (CA), Medical University of Vienna (AT), Friedrich Schiller University Jena (DE), University of Glasgow (GB), University of Birmingham (GB), Rakuno Gakuen University (JP), University of Brescia (IT), University of Otago (NZ), Temple University (US), Vrije Universiteit Amsterdam (NL), Michigan State University (US), University of Gothenburg (SE), Université Grenoble Alpes (FR), University of Toledo (US), Leipzig University (DE), Indian Institute of Technology Kanpur (IN), University of Westminster (GB), Kumamoto University (JP), University of Edinburgh (GB)
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Receptor Mechanisms and Signaling
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