Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss
Circulating MOTS-c levels are elevated in obesity, exhibiting a nonlinear relationship with BMI and insulin resistance. MOTS-c may represent a compensatory metabolic response in obesity and insulin-resistant states, highlighting its potential as a clinical biomarker. This preliminary exploratory study warrants validation in larger and independent cohorts.
Authors
- Fei Yuan (ORCID: https://orcid.org/0000-0001-5945-8567)
- Hui Tang
- Se-Hee Yoon
- James Krier
- Alfonso Eirin
- Amir Lerman
- Pinchas Cohen
- Dilbar Abdurakhimoova
- Lilach O Lerman
- Xiangyang Zhu
Institutions
- University of Southern California (US)
- Mayo Clinic (US)
- Konyang University (KR)
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Medical Center (CN)
Publication Details
- Journal
- Journal of Clinical & Translational Endocrinology
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1016/j.jcte.2025.100429
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00