Stereoselective Synthesis of Fluoroalkenes via Electrocatalytic Defluorinative Coupling

We report an electrochemically driven nickel-catalyzed protocol based on sequential ligand relay catalysis (SLRC), enabling divergent access to difluoroalkenes, monofluoroalkenes, and terminal alkenes. Mechanistic studies reveal that the directing-group-assisted SLRC process is crucial for achieving high stereoselectivity and enabling a subsequent selective defluorination step, which remains inaccessible through conventional methods.