Potential mechanism underlying HXSJ decoction in the treatment of venous leg ulcers: based on the association between venous leg ulcers and ferroptosis
This study demonstrated that iron accumulation-mediated inactivation of GPX4 serves as a crucial mechanism in VLU formation through ferroptosis induction. Notably, the therapeutic mechanism through which HXSJ decoction alleviates ferroptosis involves Nrf2/xCT/GPX4 pathway activation and a reduction in ferrous ion accumulation. These findings may provide novel insights into VLU pathogenesis and give possible reason for developing traditional Chinese medicine therapies targeting ferroptosis and VLUs.
Authors
- Lie Xiong (ORCID: https://orcid.org/0000-0002-7771-5333)
- Yanbo Shi (ORCID: https://orcid.org/0000-0002-8338-4040)
- Yujuan Su (ORCID: https://orcid.org/0000-0002-7741-3351)
- Gaofeng Fang (ORCID: https://orcid.org/0000-0001-7105-5883)
- Zhenjun Wang (ORCID: https://orcid.org/0000-0003-0700-3100)
- Sunfeng Pan (ORCID: https://orcid.org/0000-0002-9284-2111)
- Hanqiang Shi (ORCID: https://orcid.org/0000-0002-0877-9165)
- Minda Zhu (ORCID: https://orcid.org/0000-0001-8095-3888)
- Zhaoyan Liu
- Chunmao Han
- Jiakun Li
- Jiayan Li
Institutions
- Zhejiang Chinese Medical University (CN)
- Jiaxing University (CN)
- First Hospital of Jiaxing (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1186/s12906-025-05184-3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00