Comparison of In Vitro Metrics With Real-World Risk of Drug-Induced Parkinsonism Due to Antipsychotic Drugs: Retrospective Cohort Study
Integrating receptor-binding kinetics with BBB penetration may provide an in vitro framework that reflects real-world variation in DIP risk among D2R-antagonizing APDs. These findings support the relevance of combining kinetic and central nervous system exposure parameters for early safety evaluation.
Authors
- Yun Mi Yu (ORCID: https://orcid.org/0000-0002-8267-9453)
- Wootaek Lım (ORCID: https://orcid.org/0000-0002-5523-6294)
- Kwangsoo Kim
- Seungyeon Kim
- Yong Min Ahn
- Hyun Seok Lee
- Ha Young Jang
- Minseok Hong
Institutions
- Gachon University (KR)
- Yonsei University (KR)
- Eulji University (KR)
- Seoul National University Hospital (KR)
- Dankook University (KR)
Publication Details
- Journal
- JMIR Public Health and Surveillance
- Published
- 2025-12-30
- DOI
- https://doi.org/10.2196/81876
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00